It is becoming increasingly urgent for humans to maintain actively Earth’s living systems that enable and support our life: to live and let live. This is clearly not an easy task. How can we produce enough food from agroecosystems without poisoning their components or degrading the surrounding ecosystems, which we also need? How can we keep track of the essential resources that biodiversity provides for the ecosystem services supporting human societies, at scales that promote timely and well-targeted intervention? I will talk about recent and ongoing work in the Spatial Genetics group in two areas. One encompasses studies of the occurrence, distribution, and effects of chemical mediators in agroecosystems, including fields of smallholder farmers practicing mixed cropping, and vineyards of regional winegrowers, to support sustainable management of these systems while achieving higher yields. The second comprises projects applying remote sensing and Earth observation technologies to the scalable assessment and monitoring of genetic diversity for different species. This second set of projects aims to support biodiversity monitoring and management according to the global biodiversity framework, particularly the protection of species’ adaptive potential and the maintenance of ecosystem services.